Non-O Blood Type Is the Commonest Genetic Risk Factor for VTE: Results from a Meta-Analysis of the Literature

Francesco Dentali; Anna Paola Sironi; Walter Ageno; Sara Turato; Carlo Bonfanti; Francesco Frattini; Silvia Crestani; Massimo Franchini

doi:10.1055/s-0032-1315758

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2012; 38(05): 535-548
DOI: 10.1055/s-0032-1315758

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Non-O Blood Type Is the Commonest Genetic Risk Factor for VTE: Results from a Meta-Analysis of the Literature

Francesco Dentali

¹Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

,

Anna Paola Sironi

¹Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

,

Walter Ageno

¹Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

,

Sara Turato

¹Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

,

Carlo Bonfanti

²Department of Transfusion Medicine and Hematology, “C. Poma” Hospital, Mantova, Italy

,

Francesco Frattini

²Department of Transfusion Medicine and Hematology, “C. Poma” Hospital, Mantova, Italy

,

Silvia Crestani

²Department of Transfusion Medicine and Hematology, “C. Poma” Hospital, Mantova, Italy

,

Massimo Franchini

²Department of Transfusion Medicine and Hematology, “C. Poma” Hospital, Mantova, Italy

› Author Affiliations

Abstract

It is well known that the ABO blood group exerts a major influence on hemostasis, as O blood group individuals have lower von Willebrand factor and factor VIII levels than non-O blood group subjects. To evaluate the possible clinical implication of the different ABO blood groups on the risk of developing venous thromboembolism (VTE), we conducted a meta-analysis of the existing literature. After an electronic search strategy using Medline and Embase and a manual review of abstract books of the International Society on Thrombosis and Haemostasis and of reference lists of all retrieved articles, we included in the systematic review 38 studies with 10,305 VTE cases. The prevalence of non-O blood group was significantly higher in VTE patients compared with controls with a resulting pooled odds ratio (OR) of 2.09 (95% confidence interval [CI], 1.83, 2.38; p < 0.00001). Similar findings were obtained when the genotypes A₁O/BO/A₂B (OR 1.73, 95% CI, 1.47, 2.05; p < 0.00001) and A₁B/A₁A₁/BB (OR 1.87, 95% CI, 1.84, 2.44; p < 0.00001) were analyzed. The maximum VTE risk was observed in non-O–factor V Leiden patients (OR 7.60, 95% CI, 3.21, 17.99), while for G20210A prothrombin mutation it was not possible to perform a pooled analysis due to a paucity of published studies. Finally, the association between non-O blood group and VTE was weaker when provoked VTE cases were considered (OR 1.33, 95% CI, 1.18, 1.50), while it was substantially unchanged when unprovoked VTE cases were analyzed (OR 1.88, 95% CI, 1.42, 2.50). In conclusion, considering its prevalence, non-O blood group is a candidate to be one of the most important genetic risk factors for venous thrombosis.

Keywords

ABO blood group - von Willebrand factor - factor VIII - venous thromboembolism

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References

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